The preliminary regular season schedule for the 2012 season was released by Major League Baseball today. The Yanks open up the season in St. Pete against the Rays on 4/6/12. The home opener is on 4/13 against the Angels. They also end the season with three against the Red Sox at the Stadium. As for interleague, the Yanks play the Braves six times, make a trip to DC, face the Reds for three games at home, and of course, the six Subway Series games vs. the Mets.
For the entire schedule, check out this PDF via River Ave. Blues.